Method for directing cellular migration patterns on a biological tissue
AssigneeEdwards Lifesciences Corporation
InventorJulie A. Benton
Life of this patent
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Abstract
A contoured biological tissue for a bioprostheses, such as a cardiac/vascular patch or a bioprosthetic heart valve, and methods of contouring the tissue, are described. A predetermined pattern is provided on the tissue, comprising a plurality of ridges or depressions that are configured to facilitate cellular migration in a first direction and discourage cellular migration in a second direction. The biological tissue can be used in connection with a bioprosthetic heart valve comprising a biological tissue leaflet structure coupled to a supporting frame.
Claims19
A method for treating a pericardial tissue, the method comprising:
- treating a pericardial tissue surface to reduce surface irregularities;
- and
- contouring the pericardial tissue surface with a predetermined pattern comprising one or a plurality of ridges or depressions;
- wherein the one or plurality of ridges or depressions are provided to encourage cellular migration in a first direction and discourage cellular migration in a second direction.
A method for treating a pericardial tissue, the method comprising:
- cross-linking a pericardial tissue with a fixative;
- exposing the pericardial tissue to a glycerin-based treatment;
- treating the pericardial tissue surface to reduce surface irregularities;
- contouring the pericardial tissue surface with a predetermined pattern comprising one or a plurality of ridges or depressions;
- exposing the pericardial tissue to a capping agent, a reducing agent or both;
- wherein the one or plurality of ridges or depressions are provided to encourage cellular migration in a first direction and discourage cellular migration in a second direction.
Dependencies are inferred from the claim text.