# US 12,178,643 B2 · Intracardiac therapeutic and diagnostic ultrasound device

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- Number: US 12,178,643 B2
- Document ID: US12178643B2
- Status: Granted
- Kind: B2
- Application number: 15/998,480
- Filed: 2018-08-15
- Published: 2019-02-21
- Granted: 2024-12-31
- Earliest claimed: 2017-08-15
- Assignees: Philips Image Guided Therapy Corporation
- Applicants: Koninklijke Philips N.V.
- Inventors: Jeremy Stigall; Princeton Saroha; Robert Emmett Kearney
- Web page: https://patentgrep.com/patent/US12178643B2

## CPC

- A61B 8/12: in body cavities or body tracts, e.g. by using catheters
- A61B 8/445: {Details of catheter construction}
- A61B 8/4483: {characterised by features of the ultrasound transducer}
- A61B 8/4488: {the transducer being a phased array}
- A61B 8/56: {Details of data transmission or power supply}
- A61B 17/2202: {the ultrasound transducer being inside patient's body at the distal end of the catheter}
- A61N 7/022: {intracavitary}
- A61B 5/6852: {Catheters}
- A61B 18/1492: {having a flexible, catheter-like structure, e.g. for heart ablation (A61B18/1477 takes precedence)}
- A61B 2017/22008: {used or promoted}
- A61B 2017/22028: {arrays, e.g. phased arrays}
- A61B 2018/00404: {Blood vessels other than those in or around the heart}
- A61B 2018/00577: {Ablation}
- A61N 2007/0052: {using the same transducer for therapy and imaging}
- A61N 2007/0073: {using multiple frequencies}
- A61N 2007/0078: {with multiple treatment transducers}
- A61N 2007/0082: {Scanning transducers}
- A61N 2007/0095: {by modifying an excitation signal}
- A61N 2007/027: {with multiple foci created simultaneously}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

Systems, methods, and devices for using ultrasound for diagnostic and therapeutic procedures are provided. Ultrasound signals may be transmitted and/or received by ultrasound transducers in an ultrasound device positioned within the anatomy of a patient. The ultrasound transducers may be arranged in an array such that a first segment of the array is configured to transmit ultrasound pulses and receive ultrasound echoes for diagnostic procedures and a second segment of the array is configured to transmit ultrasound pulses for therapeutic procedures. The received ultrasound echoes may be used to generate two- or three-dimensional images of the anatomy.

## Claims

### Claim 1

An ultrasound system, comprising:
a flexible elongate member configured to be positioned within vasculature of a patient adjacent to an occlusion, the flexible elongate member comprising a proximal portion and a distal portion;
an ultrasound transducer array positioned at the distal portion of the flexible elongate member, wherein the ultrasound transducer array includes a plurality of independently-controlled transducer elements arranged in a first segment and a second segment, wherein the first segment is configured to emit a first ultrasound signal within a first frequency range between 10 MHz and 70 MHz and to receive ultrasound echoes reflected from the vasculature and associated with the first ultrasound signal within the first frequency range for diagnostic use, imaging of at least the occlusion, wherein the second segment is configured to emit a second ultrasound signal within a second frequency range between 20 kHz and 3 MHz for therapeutic use, including damaging a structure of the occlusion shown in the imaging;
a beamforming controller at the distal portion of the flexible elongate member, wherein the beamforming controller is configured to independently drive each of the plurality of independently-controlled transducer elements, the beamforming controller comprising an integrated circuit (IC) configured to control an angle of transmission of at least the second ultrasound signal by the second segment for producing a pattern of fractures in the occlusion with different angles, without moving the ultrasound transducer array, for damaging the structure of the occlusion, wherein the IC includes a plurality of microchannels each configured to separately beam form signals received from the independently-controlled transducer elements in the first segment, each microchannel including a delay configured to align the signals received from the independently-controlled transducer elements, the delay comprises at least one of a charge coupled device, an analog random access memory, or a tapped analog delay line; and
a plurality of signal lines coupling each of the independently-controlled transducer elements in the ultrasound transducer array to the beamforming controller.

### Claim 2 (depends on 1)

The ultrasound system of claim 1, wherein the ultrasound transducer array is a two-dimensional array of the independently controlled transducer elements, wherein the first segment comprises a first plurality of the independently controlled transducer elements disposed on a first portion of the two-dimensional array and in communication with the beamforming controller via a first one of the signal lines, and wherein the second segment comprises a second plurality of the independently controlled transducer elements disposed on a second portion of the two-dimensional array adjacent the first portion and in communication with the beamforming controller via a second one of the signal lines.

### Claim 3 (depends on 1)

The ultrasound system of claim 1, wherein the ultrasound transducer array comprises at least one of a lead zirconate titanate (PZT) transducer, a capacitive micromachined ultrasound transducer (CMUT), and a piezoelectric micromachined ultrasonic transducer (PMUT).

### Claim 4 (depends on 1)

The ultrasound system of claim 1, wherein the ultrasound transducer array is configured to direct the second ultrasound signal to a first portion of occlusion and a second portion of occlusion different from the first portion of anatomy without moving the ultrasound transducer array.

### Claim 5 (depends on 1)

The ultrasound system of claim 1, further comprising a switch to selectively switch between transmitting the first ultrasound signals with the first segment and transmitting the second ultrasound signals with the second segment.

### Claim 6 (depends on 1)

The ultrasound system of claim 1, further comprising a substrate including electrical conductors connected to the ultrasound transducer array, the electrical conductors configured to selectively switch between transmitting signals with the first segment and the second segment.

### Claim 7 (depends on 1)

The ultrasound system of claim 1, wherein the flexible elongate member comprises a first cable configured to control transmission of the first ultrasound signals of the first segment and a second cable configured to control transmission of the second ultrasound signals of the second segment.

### Claim 8 (depends on 7)

The ultrasound system of claim 7, wherein the flexible elongate member comprises a third cable configured to control transmission of both the first and second ultrasound signals of the first segment and the second segment.

### Claim 9 (depends on 1)

The ultrasound system of claim 1, further comprising:
a treatment component positioned at the distal portion of the flexible elongate member adjacent to the ultrasound transducer array, wherein the treatment component is configured to apply a treatment to the occlusion following the producing of the pattern of fractures in the occlusion by the second ultrasound signal.

### Claim 10 (depends on 9)

The ultrasound system of claim 9, wherein the treatment component comprises a targeted drug delivery device, a drug coated balloon or a drug coated stent configured to deliver a pharmacological agent to the occlusion.

### Claim 11 (depends on 9)

The ultrasound system of claim 9, wherein the treatment component comprises a balloon, a stent, a needle, an ablation electrode, a mechanical cutting component, a rotational cutting device, or an aspiration device.