Systems and methods for the detection and quantification of ammonia and ammonium in fluids
AssigneesMayo Foundation for Medical Education and Research, Arizona Board of Regents on behalf of Arizona State University
InventorsMarylaura Thomas, Leslie Thomas, Erica Forzani
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Abstract
A system with an analyzer device in fluid communication with a sample of a bodily fluid is configured to chemically or electrochemically convert at least a portion of ammonium (NH4+) contained within the bodily fluid into ammonia (NH3) and dispel the converted ammonia (NH3) into a gas sensing chamber. An ammonia (NH3) sensor located within the gas sensing chamber in conjunction with a processor can quantify an amount of ammonia (NH3) present in the gas sensing chamber in relation to the total ammonia of the bodily fluid.
Claims21
A system comprising an analyzer device configured to be in communication with a sample of bodily fluid, the analyzer device comprising:
- a sensing chamber;
- an extractor configured to:
- (i) be located between a source of the sample of bodily fluid and the sensing chamber, (ii) extract ammonia (NH3) from ammonium (NH4+) present in the sample of bodily fluid, and (iii) dispel the ammonia (NH3) into the sensing chamber;
- and
- a first sensor associated with the sensing chamber and configured to quantify an amount of the ammonia (NH3) present in the sensing chamber,
- wherein the analyzer device is configured to detect at least one of:
- altered organ function, altered tissue function, and altered metabolic status based on the quantified amount of the ammonia (NH3).
Dependencies are inferred from the claim text.