# US 12,178,548 B2 · System and method for laser based internal analysis of gases in a body of a human

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- Number: US 12,178,548 B2
- Document ID: US12178548B2
- Status: Granted
- Kind: B2
- Application number: 18/224,882
- Filed: 2023-07-21
- Published: 2023-11-30
- Granted: 2024-12-31
- Earliest claimed: 2015-08-17
- Assignees: Neola Medical AB
- Applicants: Neola Medical AB
- Inventors: Sune Svanberg; Emilie Krite Svanberg; Marcus Larsson
- Web page: https://patentgrep.com/patent/US12178548B2

## CPC

- A61B 5/0084: {for introduction into the body, e.g. by catheters (A61B5/1459 takes precedence)}
- A61B 1/00013: {using optical means}
- A61B 1/00165: {with light-conductive means, e.g. fibre optics (A61B1/07 takes precedence)}
- A61B 1/063: {for monochromatic or narrow-band illumination}
- A61B 1/07: using light-conductive means, e.g. optical fibres
- A61B 1/267: for the respiratory tract, e.g. laryngoscopes or bronchoscopes
- A61B 1/2676: {Bronchoscopes}
- A61B 1/2733: {Oesophagoscopes}
- A61B 1/31: for the rectum, e.g. proctoscopes or sigmoidoscopes
- A61B 5/0059: {using light, e.g. diagnosis by transillumination, diascopy, fluorescence (photoacoustic A61B5/0093; optical measurement of heart rate A61B5/02416; optical measurement of blood flow A61B5/0261; optical measurement of analytes A61B5/1455)}
- A61B 5/0075: {by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy (A61B5/0071 takes precedence)}
- A61B 5/08: Measuring devices for evaluating the respiratory organs
- A61B 5/4839: {combined with drug delivery}
- A61B 5/6853: {with a balloon}
- A61B 5/746: {Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms}
- A61M 16/024: {including calculation means, e.g. using a processor}
- G01J 3/42: Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry (beam switching arrangements G01J3/08)
- G01N 21/49: within a body or fluid
- A61B 1/00: Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes (examination of body cavities or body tracts using ultrasonic, sonic or infrasonic waves A61B8/12; endoscopic instruments for taking cell samples or for biopsy A61B10/04); Illuminating arrangements therefor (for the eyes A61B3/00)
- A61B 1/0661: {Endoscope light sources}
- A61B 2090/3618: {with a mirror}
- A61B 2562/0238: Optical sensor arrangements for performing transmission measurements on body tissue
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- G01J: MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY (light sources F21, H01J, H01K, H05B; investigating properties of materials by optical means G01N)
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

A device, system and method for measuring free gas in a cavity of a subject. The device, system and method include a light source for emitting light with a wavelength associated with an absorption band of the free gas, an optical fibre connected to the light source and adapted to be inserted using an introducing member for internal illumination, and a detector adapted to be positioned on a skin surface for detecting light transmitted through the tissue. The device, system and method further includes a control unit for evaluating the detected transmitted light for determining the free gas, or a distribution of the free gas, or concentration of the free gas.

## Claims

### Claim 1

A system for determining a lung function of a subject, the system comprising:
a light source configured for externally emitting light with a wavelength into the subject at more than one location and wherein the light source comprises a diffusor, and wherein the wavelength is associated with an absorption band of a free gas in a lung of the subject;
a plurality of detector units adapted to be positioned on a skin surface for detecting light transmitted through tissue and a cavity of the lung; and
a control unit for evaluating the detected light for determining functioning of the lung of the subject.

### Claim 2 (depends on 1)

The system of claim 1, wherein the light source is a laser.

### Claim 3 (depends on 1)

The system of claim 1, further comprising at least two light sources having different wavelengths.

### Claim 4 (depends on 3)

The system of claim 3, wherein at least one light source has a wavelength associated with an absorption band of a reference gas.

### Claim 5 (depends on 4)

The system of claim 4, wherein the reference gas is water vapour.

### Claim 6 (depends on 1)

The system of claim 1, wherein the free gas is a physiological gas or a mixture of gases.

### Claim 7 (depends on 6)

The system of claim 6, wherein the physiological gas comprises at least one gas selected from the group consisting of oxygen, nitric oxide, carbon dioxide, and water vapour.

### Claim 8 (depends on 1)

The system of claim 1, wherein the control unit is configured for controlling a medical ventilator based on the distribution of the free gas, or the concentration of the free gas.

### Claim 9 (depends on 1)

The system of claim 1, wherein the control unit is configured for controlling an administration of a medicament based on the distribution of the free gas, or the concentration of the free gas.

### Claim 10 (depends on 1)

The system of claim 1, wherein the control unit is configured for activating an alarm when the determined free gas, the distribution of the free gas, or the concentration of the free gas reaches or passes a selected threshold value.

### Claim 11 (depends on 10)

The system of claim 10, wherein evaluation is obtained as a three-dimensional gas distribution.

### Claim 12 (depends on 1)

The system of claim 1, wherein the plurality of detector units comprise at least one imaging sensor, an absorbing wavelength and a close non-absorbing wavelength are sequentially emittable by the light source sequentially, two images are detectable by the plurality of image sensors, and detected two images are comparable by the control unit.

### Claim 13 (depends on 1)

The device of claim 1, wherein line profile changes are evaluatable in an absorption spectrum by the control unit for determining the distribution of the free gas, or the concentration of the free gas.