# US 12,178,223 B2 · Insect life cycle interruption agent(LCIA) formulations and their manufacture and use

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- Number: US 12,178,223 B2
- Document ID: US12178223B2
- Status: Granted
- Kind: B2
- Application number: 18/022,042
- Filed: 2021-08-02
- Published: 2023-07-20
- Granted: 2024-12-31
- Earliest claimed: 2020-08-18
- Assignees: Bergman Industries Ltd
- Applicants: Bergman Industries Ltd
- Inventors: Anat Hoyzman; Yoav Blatt; Ashgan Beshara; Elisheva Ohana; Shimon Elmaliah; Udi Reiss
- Web page: https://patentgrep.com/patent/US12178223B2

## CPC

- A23K 20/137: containing two hetero atoms, of which at least one is nitrogen
- A01N 43/68: with two or three nitrogen atoms directly attached to ring carbon atoms
- A01P 7/04: Insecticides
- A23K 10/30: from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms (obtained by microbiological or biochemical processes, e.g. using yeasts or enzymes, A23K10/10)
- A23K 20/105: Aliphatic or alicyclic compounds
- A23K 20/111: Aromatic compounds
- A23K 20/121: containing oxygen or sulfur as hetero atom
- A23K 20/158: Fatty acids; Fats; Products containing oils or fats
- A23K 20/163: Sugars; Polysaccharides
- A23K 20/184: Hormones
- A23K 20/28: Silicates, e.g. perlites, zeolites or bentonites
- A23K 40/10: by agglomeration; by granulation, e.g. making powders
- A23K 40/30: by encapsulating; by coating
- A23K 40/35: Making capsules specially adapted for ruminants
- A23K 50/10: for ruminants
- A23K 50/75: for poultry
- A23K: FODDER
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01P: BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS

## Abstract

An in-feed life cycle interruption agent (LCIA) including a granulated core comprising LCIA material and a coating on the core. Related methods and products are also disclosed. Examples of LCIA include, but are not limited to Naturally occurring insect toxins (NOIT such as saponin and Insect Growth Regulators (IFR) such as Cyromazine.

## Claims

### Claim 1

An in-feed life cycle interruption agent (LCIA) comprising:
(a) a granulated core comprising at least one active ingredient selected from the group consisting of saponin and cyromazine; and
(b) a coating on said granulated core, the coating (i) protects said active ingredient from inactivation during passage through the entire digestive tract; and (ii) comprises an enteric coating, the enteric coating has at least one member selected from the group consisting of hydroxypropyl methylcellulose phthalate (HP-55), Stearic acid, Zein, cellulose acetate phthalate, cellulose acetate succinate, methacrylic polymer, shellac, and alginate.

### Claim 2 (depends on 1)

The in-feed LCIA according to claim 1, wherein said coating comprises an enteric coating, the enteric coating protects said active ingredient from inactivation as the in-feed LCIA passes through the digestive tract, the enteric coating has at least one member selected from the group consisting of hydroxypropyl methylcellulose phthalate (HP-55), Stearic acid, Zein, cellulose acetate phthalate, cellulose acetate succinate, methacrylic polymer, shellac, and alginate.

### Claim 3 (depends on 2)

The in-feed LCIA according to claim 2, wherein said enteric coating comprises at least one member selected from the group consisting of hydroxypropyl methylcellulose phthalate (HP-55) and stearic acid.

### Claim 4 (depends on 1)

The in-feed LCIA according to claim 1, further comprising;
an additional coating that protects said active ingredient from inactivation in a rumen, the additional coating is selected from the group consisting of fat, wax, hard oil, palm oil, palm kernel oil, coconut oil, rape seed oil, sunflower oil, corn oil, castor oil, Cocoa butter, Shea butter, butter, animal fat, and hydrogenated vegetable oils, cellulose derivatives, ethyl cellulose, cellulose acetate, ethyl acrylate, methyl methacrylate, and zein.

### Claim 5 (depends on 1)

The in-feed LCIA according to claim 1, wherein said granulated core further comprises one or more members selected from the group consisting of silica, microcrystalline cellulose, sugar, starch, calcium salts and other inert materials.

### Claim 6 (depends on 1)

The in-feed LCIA according to claim 1, wherein said active ingredient comprises saponin.

### Claim 7 (depends on 6)

The in-feed LCIA according to claim 6, wherein said saponin comprises Yucca derived material.

### Claim 8 (depends on 1)

The in-feed LCIA according to claim 1, wherein said active ingredient comprises cyromazine.