# US 12,178,206 B2 · Apparatus for tissue transport and preservation

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- Number: US 12,178,206 B2
- Document ID: US12178206B2
- Status: Granted
- Kind: B2
- Application number: 18/305,977
- Filed: 2023-04-24
- Published: 2023-11-23
- Granted: 2024-12-31
- Earliest claimed: 2020-01-31
- Assignees: Paragonix Technologies, Inc.
- Applicants: Paragonix Technologies, Inc.
- Inventors: Adam Collette; Melanie Jessel; Lisa Maria Anderson
- Web page: https://patentgrep.com/patent/US12178206B2

## CPC

- A01N 1/148: with provisions specially adapted for transporting
- A01N 1/143: for organ perfusion
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS

## Abstract

Systems and methods of the invention generally relate to prolonging viability of bodily tissue, especially an organ such as a lung, by adjusting pressure as needed to maintain a constant pressure within the organ even during external pressure fluctuations due, for example, to transportation of the organ in an airplane. Gas passing into and out of the organ may be conditioned to prolong tissue viability.

## Claims

### Claim 1

A system for transport of a lung, the system comprising:
a pump configured to direct gas into an airway of a lung to inflate a cavity of the lung with gas, the gas configured to maintain inflation of the lung;
a pressure relief valve configured to release gas when pressure within the cavity of the lung is above a high-pressure threshold while the pump is directing gas into the airway of the lung; and
a lung adapter configured to be in fluid communication with the pump, the pressure relief valve, and the airway of the lung,
wherein the pressure relief valve and the pump are configured to maintain a desired internal pressure in the cavity of the lung.

### Claim 2 (depends on 1)

The system of claim 1, wherein the airway of the lung is selected from a group consisting of a trachea or bronchus of the lung.

### Claim 3 (depends on 1)

The system of claim 1, further comprising one or more sensors configured to sense a parameter within the system.

### Claim 4 (depends on 1)

The system of claim 1, further comprising a cooling element.

### Claim 5 (depends on 4)

The system of claim 4, wherein the cooling element is in-line between the pump and the airway of the lung and operable to cool gas traveling therebetween.

### Claim 6 (depends on 1)

The system of claim 1, further comprising a humidifying element in-line between the pump and the airway of the lung and operable to humidify gas traveling therebetween.

### Claim 7 (depends on 1)

The system of claim 1, further comprising insulated tubing in fluid communication with the pump, the pressure relief valve, and the lung adapter.

### Claim 8 (depends on 1)

The system of claim 1, further comprising a compressive sleeve operable to compress the lung.

### Claim 9 (depends on 8)

The system of claim 8, wherein the compressive sleeve comprises one or more inflatable cavities.

### Claim 10 (depends on 9)

The system of claim 9, wherein the pump is configured to inflate and deflate the one or more inflatable cavities in a cyclic pattern to provide pulsatile compressive force on the lung.

### Claim 11 (depends on 1)

The system of claim 1, wherein constant pressure is 10-15 cmH2O.

### Claim 12

A method for transport of a lung, the method comprising:
providing a lung container comprising a lung adapter, a pump configured to direct gas into an airway of a lung to inflate a cavity of the lung with gas, the gas configured to maintain inflation of the lung, and a pressure relief valve configured to release gas when pressure within the cavity of the lung is above a high-pressure threshold while the pump is directing gas into the airway of the lung, the lung adapter configured to be in fluid communication with the pump and the pressure relief valve;
coupling the airway of the lung to the lung adapter to form a closed air system; and
maintaining a desired internal pressure in the cavity of the lung via the pump and the pressure relief valve.

### Claim 13 (depends on 12)

The method of claim 12, wherein the airway of the lung is selected from a group consisting of a trachea or bronchus of the lung.

### Claim 14 (depends on 12)

The method of claim 12, further comprising cooling gas travelling to the airway of the lung with an in-line cooling element.

### Claim 15 (depends on 12)

The method of claim 12, further comprising cooling gas travelling to the airway of the lung with a cooling element.

### Claim 16 (depends on 12)

The method of claim 12, further comprising humidifying gas travelling to the airway of the lung with an in-line humidifying element.

### Claim 17 (depends on 12)

The method of claim 12, further comprising compressing the lung with a compressive sleeve.

### Claim 18 (depends on 17)

The method of claim 17, wherein the compressive sleeve comprises one or more inflatable cavities.

### Claim 19 (depends on 18)

The method of claim 18, further comprising compressing the lung in a cyclic pattern to provide pulsatile compressive force on the lung by inflating and deflating the one or more inflatable cavities.

### Claim 20 (depends on 12)

The method of claim 12, wherein constant pressure is 10-15 cmH2O.

### Claim 21 (depends on 1)

The system of claim 1, wherein the pump is configured to pump a pulsatile or cyclic flow of gas into the airway of the lung.