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US 12,174,182 B2Granted
Plasmonic biosensor
AssigneeEcole Polytechnique Federale De Lausanne (Epfl)
InventorsAlexander Belushkin, Filiz Yesilköy, Hatice Yanik Altug
Life of this patent
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Abstract
The present invention relates to a plasmonic biosensor system. The system includes a nano-hole array device comprising at least one nano-hole array (NHA) including at least one or a plurality of nano holes (NH), an image sensor (A3) for capturing light provided by a light source (A1) and transmitted through the nano-hole array (NHA), and at least one or a plurality of nano-particles (NP) configured to be received by the nano-holes (NH) of the nano-hole array (NHA).
Claims16
Plasmonic biosensor system including:
- a nano-hole array device comprising at least one nano-hole array including a plurality of nano holes, the at least one nano-hole array is functionalized by at least one molecule attached to the at least one nano-hole array to bind to a target antigen or biomarker,
- an image sensor for capturing light provided by a light source for illuminating the at least one nano-hole array and transmitted through the at least one nano-hole array, and
- at least one or a plurality of nano-particles configured to be received by the nano-holes of the at least one nano-hole array, the at least one or the plurality of nano-particles comprising at least one metal and the at least one or the plurality of nano-particles are functionalized by at least one further molecule attached to the at least one or each nano-particle, the at least one further molecule configured to bind or conjugate to a target antigen or biomarker,
- wherein the nano-holes are configured to produce an extraordinary optical transmission resonance;
- and
- wherein the system further includes a processor configured to receive image data from the image sensor and configured to determine or count, from the received image data, the nano-holes on the at least one nano-hole array having received a single nano-particle at which a quenching of transmission intensity of an extraordinary optical transmission occurs.
3 more elements
Plasmonic bio-sensing method including the steps of:
- providing a nano-hole array device comprising at least one nano-hole array including a plurality of nano holes,
- providing a light source for illuminating the at least one nano-hole array,
- providing an image sensor for capturing light provided by the light source and transmitted through the at least one nano-hole array, and
- providing at least one or a plurality of nano-particles configured to be received by the nano-holes of the at least one nano-hole array, the at least one or the plurality of nano-particles comprising or consisting solely of at least one metal;
- and
- functionalizing the at least one nano-hole array to capture a target antigen or biomarker, by attaching at least one molecule to the at least one nano-hole array, the at least one molecule being configured to bind to a target antigen or biomarker;
- and
- functionalizing the at least one or the plurality of nano-particles with at least one molecule configured to bind or conjugate to the target antigen or biomarker by attaching at least one further molecule to the at least one or each nano-particle, the at least one further molecule being configured to bind or conjugate to a target antigen or biomarker;
- wherein the nano-holes are configured to produce an extraordinary optical transmission resonance, and
- wherein the method further includes the step of determining or counting, from received image data, the nano-holes on the at least one nano-hole array having received a single nano-particle and at which a quenching of transmission intensity of an extraordinary optical transmission resonance occurs.
7 more elements
Dependencies are inferred from the claim text.