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US 12,173,045 B2Granted
Human alpha fetoprotein-specific t cell receptors and uses thereof
AssigneeAugusta University Research Institute, Inc.
InventorsYukai He, Wei Zhu, Esteban Celis, Yibing Peng, Lan Wang
Life of this patent
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Abstract
T cell receptors that specifically recognize hAFP158 and methods of their use are provided.
Claims5
A method for treating an HLA-A2/Hafp158 expressing cancer in a subject in need thereof, the method comprising administering said subject a therapeutically effective amount of CD4 and/or CD8 T cells comprising a recombinant T cell receptor (TCR) comprising a Vα domain and a Vβ domain,
- (a) the Vα domain comprising three complementarity determining regions (CDRs), CDR1, CDR2 and CDR3, wherein CDR1 comprises an amino acid sequence of DRNVDY (residues 47 to 52 of SEQ ID NO:2), wherein CDR2 comprises an amino acid sequence of IFSNGE (residues 70 to 75 of SEQ ID NO:2), and wherein CDR3 comprises an amino acid sequence set forth in SEQ ID NO:
- 29;
- and
- (b) the Vβ domain comprising three CDRs, CDR1, CDR2 and CDR3, wherein CDR1 comprises an amino acid sequence of NSHNY (residues 44 to 48 of SEQ ID NO:11), wherein CDR2 comprises an amino acid sequence of SYGAGN (residues 66 to 71 of SEQ ID NO:
- 11), and wherein CDR3 comprises an amino acid sequence set forth in SEQ ID NO:
- 37.
3 more elements
Dependencies are inferred from the claim text.