Deuterated secnidazole for use in the treatment of bacterial vaginosis and methods and uses thereof
AssigneeEvofem Biosciences, Inc.
InventorsRichard John Holl, Kurt Nielsen, James Garegnani
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Abstract
The present invention is related to deuterated secnidazole, a prodrug thereof, a hydrate thereof, a solvate thereof, a polymorph thereof, or a pharmaceutically acceptable salt thereof and its use for the treatment of bacterial vaginosis or trichomoniasis in a subject in need thereof. The present invention is also related to pharmaceutical compositions and methods and uses of treating bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, or a combination thereof.
Claims23
A compound of formula I:
- or a pharmaceutically acceptable salt thereof,
- wherein X4, X5, and X6 are deuterium, and
- wherein X1, X2, X3, X7, X8, X9, and X10 are hydrogen.
A method for treating bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, or a combination thereof in a subject in need thereof comprising:
- selecting the subject in need of treatment for bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, or a combination thereof;
- and
- administering to the subject a therapeutically effective amount of a compound of formula I,
- wherein the compound of formula I is:
- or a pharmaceutically acceptable salt thereof,
- wherein X4, X5, and X6 are deuterium, and
- wherein X1, X2, X3, X7, X8, X9, and X10 are hydrogen.
Dependencies are inferred from the claim text.