Combination therapy of electric fields and an additional treatment for cancer and imaging
AssigneeUniversity of Cincinnati
InventorsXiaoyang Qi, Ahmet Kaynak, Daria Narmoneva, Andrei Kogan
Life of this patent
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Abstract
A method of treating cancer is disclosed. The method involves applying one or more direct current electric fields (DC-EFs) to a subject and administering to the subject an additional treatment selected from the group consisting of radiation, an effective amount of one or more chemotherapy agents, SapC-DOPS, anti-phosphatidylserine targeted drugs, and combinations thereof.
Claims11
A method of treating cancer in a subject who is in need thereof, comprising applying one or more direct current electric fields (DC-EFs) to the subject and administering to said subject an additional treatment selected from the group consisting of Saposin C (SapC) and dioleoylphosphatidylserine (DOPS) (SapC-DOPS), anti-phosphatidylserine targeted drugs, and combinations thereof, wherein the magnitude of the applied DC-EF is from 100 V/cm to 1,500 V/cm.
A method of killing or inhibiting the growth of cancer cells in a target region, the method comprising the steps of:
- a. applying, to the target region, one or more direct current electric fields (DC-EFs), wherein the applied DC-EF has a magnitude from 100 V/cm to 1,500 V/cm;
- and
- b. treating the cancer cells with additional treatment selected from the group consisting of radiation, an effective amount of Saposin C (SapC) and dioleoylphosphatidylserine (DOPS) (SapC-DOPS), anti-phosphatidylserine targeted drugs, and combinations thereof.
A method of imaging cancerous cells in a subject comprising:
- a. applying one or more direct current electric fields (DC-EFs) to the subject, wherein the magnitude of the applied DC-EF is from 100 V/cm to 1,500 V/cm;
- b. administering to said subject an additional treatment of SapC-DOPS, wherein the SapC-DOPS treatment comprises one or more contrast agents;
- and
- c. detecting the one or more contrast agents in the subject.
Dependencies are inferred from the claim text.