Implants having a drug load of an oxysterol and methods of use
AssigneeWarsaw Orthopedic, Inc.
InventorsBenjamin T. Reves, David S. Scher, Roger E. Harrington, Jerbrena C. Jacobs
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Abstract
Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth. The compression resistant implant comprises a biodegradable polymer in an amount of about 0.1 wt % to about 20 wt % of the implant and a freeze-dried oxysterol in an amount of about 5 wt % to about 90 wt % of the implant. Methods of making and use are further provided.
Claims18
A compression resistant implant configured to fit at or near a bone defect to promote bone growth, the compression resistant implant comprising a biodegradable polymer in an amount of about 0.1 wt % to about 20 wt % of the implant and a freeze-dried oxysterol in monohydrate form having a particle size of about 5 microns to about 100 microns in an amount of about 5 wt % to about 90 wt % of the implant.
An implantable matrix configured to fit at or near a bone defect site to promote bone growth, the matrix comprising:
- a crosslinked biodegradable polymer in an amount of about 0.1 wt % to about 15 wt % of the matrix and a freeze-dried oxysterol in monohydrate form having a particle size of about 5 microns to about 100 microns in an amount of about 5 wt % to about 90 wt % of the matrix, the oxysterol having a concentration of about 1 mg/cc to about 1.0 g/cc.
Dependencies are inferred from the claim text.