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US 12,171,884 B2Granted
Mesoporous silica nanoparticles with lipid bilayer coating for cargo delivery
AssigneeThe Regents of the University of California
InventorsAndre E. Nel, Huan Meng, Xiangsheng Liu
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Abstract
A nanocarrier including a silica body having a surface and defining a plurality of pores that are suitable to receive molecules therein is described. The nanocarrier also includes a lipid bilayer coating the surface, and a cargo-trapping agent within the phospholipid bilayer. The phospholipid bilayer stably seals the plurality of pores. The cargo-trapping reagent can be selected to interact with a desired cargo, such as a drug.
Claims22
A method of making a drug nanocarrier, comprising:
- providing a nanocarrier comprising a silica body having a surface including a plurality of pores suitable to receive molecules therein, disposing a cargo trapping agent within the plurality of pores;
- coating the plurality of pores of the nanocarrier with a phospholipid bilayer, wherein the phospholipid bilayer encapsulates said silica body and seals the plurality of pores;
- and
- introducing a cargo comprising a drug into the plurality of pores, so that a phospholipid bilayer coated drug nanocarrier is made, wherein the nanocarrier shows <5% drug leakage over 24 hours in a biological buffer with pH of 7.4 at 37° C.
1 more element
A method of making a nanocarrier, comprising:
- providing an unloaded nanocarrier including a silica body having a surface and defining a plurality of pores that are suitable to receive molecules therein, and a phospholipid bilayer coating the surface;
- and
- encapsulating a cargo-trapping agent within the phospholipid bilayer.
Dependencies are inferred from the claim text.