Metformin tablet for relieving pain and reducing inflammation and manufacturing method thereof

A metformin tablet for relieving pain and reducing inflammation, comprising:

• a filler comprising microcrystalline cellulose and silicified microcrystalline cellulose;
• a diluent comprising mannitol and a sugar alcohol;
• an excipient comprising polyvinylpyrrolidone (PVP) and polyethylene glycol (PEG);
• a binder comprising glucose and lactose;
• a slow-release agent comprising at least one of polylactic acid;
• a sweetener comprising isomalt;
• a medicinal powder comprising metformin and the excipient;
• a disintegrant;
• and
• a lubricant;
• wherein the metformin tablet comprises a hollow part, a first colloidal layer formed on an outer surface of the hollow part, and a second colloidal layer formed on an outer surface of the first colloidal layer;
• wherein the first colloidal layer is thicker than the second colloidal layer, and is composed of a mixture of the filler having 2% to 22% by weight of the first colloidal layer, the diluent having 3% to 24% by weight of the first colloidal layer, the excipient having 1% to 25% by weight of the first colloidal layer, the binder having 0.5% to 18% by weight of the first colloidal layer, the slow-release agent having 0.1% to 12% by weight of the first colloidal layer, and the sweetener having 1% to 22% by weight of the first colloidal layer;
• and
• the second colloidal layer of the tablet is composed of a mixture of the filler having 2% to 22% by weight of the second colloidal layer, the diluent having 3% to 24% by weight of the second colloidal layer, the excipient having 1% to 25% by weight of the second colloidal layer, the binder having 0.5% to 18% by weight of the second colloidal layer, the slow-release agent having 0.1% to 12% by weight of the second colloidal layer, the sweetener having 1% to 22% by weight of the second colloidal layer, and the medicinal powder.