Use of salidroside derivative in external preparation for skin whitening
AssigneeShanghai Cheermore Biological Technology Co., Ltd.
InventorsCaibin Zhu, Junxiang Li
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Abstract
The use of the compound or a pharmaceutically acceptable salt thereof in the preparation of an external preparation for skin whitening is provided, and the compound is shown in formula (I-1): The present disclosure can enhance the whitening activity of salidroside while taking full advantage of the protective effect of salidroside sugar ring, where the phenol residues of salidroside are restructured to obtain salidroside-plus (SP-037), which is 1-(3,5-dihydroxyphenyl)ethyl-β-D-glucoside and/or a salt thereof. The whitening effect of the compound is tested through a series of experiments.
Claims7
A method of whitening skin with a skin whitening compound or a pharmaceutically acceptable salt of the skin whitening compound, the skin whitening compound consists of formula (I-1):
- the method comprising:
- applying the skin whitening compound or the pharmaceutically acceptable salt of the skin whitening compound to skin of a human subject, and
- inhibiting melanocyte production of melanin in the skin with the applied skin whitening compound or pharmaceutically acceptable salt of the skin whitening compound to thereby whitening the skin by reducing melanin content in the skin.
Dependencies are inferred from the claim text.