Method for hyperthermially treating a cancer
AssigneeImam Abdulrahman Bin Faisal University
InventorsB. Rabindran Jermy, Vijaya Ravinayagam, Dana Almohazey
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Abstract
A nanomedicinal composition comprising a nanocarrier and a pharmaceutical agent mixture comprising an anti-cancer therapeutic and an antioxidant. The nanocarrier comprises a porous silicate matrix and particles of a magnetic ferrite disposed in the pores of the porous silicate matrix. The pharmaceutical agent mixture is disposed in the pores and/or on the surface of the nanocarrier by a solution phase impregnation process. The nanomedicinal composition is used in a method of treating breast cancer.
Claims9
A method for hyperthermially treating a subject having a breast cancer, comprising:
- administering to the subject a pharmaceutical composition comprising a nanomedicinal composition,
- after delivery of the nanomedicinal composition to a breast cancer tumor site in the subject, exposing the subject to an alternating magnetic field, thereby raising the temperature of the nanomedicinal composition in the subject to hyperthermially treat the breast cancer;
- wherein the nanomedicinal composition comprises:
- a nanocarrier comprising:
- mesosilicalite;
- and
- particles of a magnetic ferrite of formula MFe2O4 disposed in the pores of the mesosilicalite, where M is Cu;
- and
- a pharmaceutical agent mixture comprising cisplatin and curcumin disposed in the pores and/or on a surface of the nanocarrier;
- wherein the nanocarrier has a BET surface area of 70 m2/g and an average pore volume of 0.1 cm3/g,
- wherein the nanomedicinal composition releases 88% of the cisplatin and 40-50% of the curcumin over 72 hours in a solution with a pH of 5.6.
Dependencies are inferred from the claim text.