Infectious plasmodium sporozoites grown in vitro
AssigneeSanaria Inc.
InventorsAbraham G. Eappen, Stephen L. Hoffman
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Abstract
The application is directed to in vitro-reared Plasmodium sporozoites of human host range wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same. Provided herein are in vitro-reared infectious Plasmodium sporozoites (SPZ) of human host range, particularly P. falciparum, P. vivax, P. ovale, P. malariae, and P. knowlesi, wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same.
Claims7
A composition comprising in vitro-reared Plasmodium-species ookinetes of human host range wherein development of the ookinetes from gametocyte stage was in a culture external to mosquitoes, wherein the composition is absent any mosquito material.
Dependencies are inferred from the claim text.