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US 12,171,753 B2Granted
Crystalline forms of ALDH2 modulators
AssigneeSophrosyne Pharmaceuticals Limited
InventorsLewis Feldberg, Akram Sabouni, Thomas R. Bailey, Vincent Wing-Fai Tai, Tom Leyssens
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Abstract
Provided herein are novel crystalline forms of a compound that acts as an ALDH2 effector, processes for preparing the crystalline forms of the compound with or without coformer, and uses thereof.
Claims21
A co-crystalline form comprising
- a compound having a formula of
- and
- a coformer, wherein the coformer is urea, 3,5-dihydroxybenzoic acid, trimesic acid, ellagic acid, MgCl2, or CaCl2), or any combination thereof,
- wherein
- n is 0-6;
- m is 0-6;
- and
- p is 0-6.
5 more elements
A process for preparing a co-crystalline form of a compound having a formula of
- wherein n is 0-6, m is 0-6, and p is 0-6;
- and a coformer, wherein the coformer is urea, 3,5-dihydroxybenzoic acid, trimesic acid, ellagic acid, MgCl2, or CaCl2), or any combination thereof,
- wherein the process comprises co-crystallizing the compound and the coformer to form the co-crystalline form of the compound and the coformer.
Dependencies are inferred from the claim text.