US 12,171,748 B2 · Nitroimidazole formulations

Abstract

The disclosure relates to nitroimidazoles and related compounds and derivatives, formulations thereof, and their use in the prevention and/or treatment of infectious disease in animals. In particular, the disclosure relates to 5-nitroimidazoles and related compounds and derivatives, formulations thereof, and their use in the prevention and/or treatment of infectious disease in animals including bacterial, viral, parasitic or fungal infections. More particularly, the invention relates to metronidazole and related compounds and derivatives, formulations thereof, and their use in the prevention and/or treatment of infectious disease caused by Clostridium species. Most preferably, the nitroimidazole is metronidazole administered in combination with berberine, or a berberine alkaloid, in a synergistic weight ratio of 1:1 or 1:2.

Claims9

Dependent claims

A method for the prevention or treatment of an infectious disease in a mammal caused by an antibiotic-resistant bacterial strain from the genus Clostridium, comprising administering an effective amount of a composition comprising a 5-nitroimidazole selected from the group consisting of:

metronidazole;
azanidazole;
bamnidazole;
carnidazole;
dimetridazole;
fexinidazole;
ipronidazole;
“MCA” nitroimidazole;
5-nitromegazol;
“MF” nitroimidazole;
nimorazole;
ornidazole;
panidazole;
ronidazole;
secnidazole;
sulphimidazole;
ternidazole, tinidazole, and acceptable salts thereof and a berberine alkaloid or salts thereof, wherein the 5-nitroimidazole and the berberine alkaloid are in a weight ratio of between 1:10 and 10:1 by dosage.

14 more elements

Dependencies are inferred from the claim text.

Nitroimidazole formulations

Life of this patent

Nitroimidazole formulations

Life of this patent

Abstract

Claims9