Pathogenic bacteria
AssigneeSporegen Limited
InventorsSimon Cutting, Hong Huynh
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Abstract
The present invention relates to pathogenic bacteria, and is particularly concerned with treating, preventing or ameliorating bacterial infections using novel antibiotic compositions. The invention is especially useful for treating infections of Bacillus and Clostridia species, such as Clostridium difficile, Staphylococcus aureus and Mycobacterium spp. The invention extends to pharmaceutical compositions comprising such formulations. The invention also extends to methods for identifying aerobic Bacillus spp., which exhibit antibacterial activity against other bacteria, such as C. difficile, and to methods for isolating active antibacterial compositions from these aerobic Bacillus spp.
Claims36
An antibiotic composition comprising precipitated micelles comprising:
- (i) an antibiotic, wherein the antibiotic is Chlorotetaine, and (ii) a lipopeptide selected from the group consisting of a member of the Surfactin family, a member of the Iturin family and a member of the Fengycin family, wherein the lipopeptide facilitates the formation of micelles, and wherein the micelle incorporates or absorbs the antibiotic.
A precipitated micelle comprising a lipopeptide, wherein the micelle has incorporated or absorbed an antibiotic, wherein the antibiotic is chlorotetaine.
Dependencies are inferred from the claim text.