Method and apparatus for manufacturing microtablets
AssigneeInCube Labs, LLC
InventorsMir A. Imran, Arthur Hsu Chen Chang, Chang Jin Ong, Delia Anna Gratta
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Abstract
Embodiments provide methods and apparatus for manufacturing a microtablet from a precursor material such as a pharmaceutical powder. Various embodiments provide a method which includes compressing the powder to form a compressed mass of a selected density and repeatedly compacting the compressed mass to increase the density of the compressed mass and form a microtablet. Related methods and apparatus are provided.
Claims26
A method of manufacturing a microtablet from a pharmaceutical powder for ingestion by a human, the method including the steps of:
- directing the powder in a first direction with a first movable member to form a collected mass of powder at a first density;
- compacting the collected mass in a second direction with a second movable member to form a compacted mass of powder;
- and
- repeatedly compacting the compacted mass of powder to incrementally increase the density of the compacted mass of powder and form a solid microtablet having a compressed mass at a final density and shape.
A method of manufacturing a microtablet from a pharmaceutical powder comprising at least one of a protein, peptide and antibody for ingestion by a human, the method including the steps of:
- compacting the powder in a first direction with a first movable compacting member and compacting the powder in a second direction with a second movable compacting member to form a compact cylindrical mass of the powder extending along a longitudinal axis;
- and
- repeatedly compacting the compact cylindrical mass along the longitudinal axis alongside the first movable compacting member and the second movable compacting member with a reciprocating cylindrical member.
A method for forming a microscale shaped mass, the method comprising:
- providing material into a fill area of a device, thereby initiating an automated process comprising:
- a) pushing the material out of the fill area in a first direction with a first movable member into a formation area of the device;
- b) tamping the material into the formation area in a second direction with a second movable member;
- c) compressing the material in the formation area of the device into the microscale shaped mass having a perimeter conforming to an inner surface of the formation area;
- and
- d) ejecting the microscale shaped mass.
Dependencies are inferred from the claim text.