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US 12,168,763 B2Granted
Microorganisms and methods for reducing bacterial contamination
AssigneeMelio Peptide Systems Inc.
InventorsSteve Good-Sung Wong, Hendrik Jurgens Jansen Van Vuuren
Life of this patent
Estimating the term…
Abstract
Provided herein are compositions and methods for reducing bacterial contamination during cell culture. Such compositions and methods utilize engineered peptides or recombinant cells capable of secreting such peptides into culture medium. Also provided are methods of using the engineered peptides for inhibiting bacterial growth during culturing of cells.
Claims20
An isolated polynucleotide comprising a nucleotide sequence encoding an engineered persulcatusin, wherein the engineered persulcatusin comprises a variant of the amino acid sequence of SEQ ID NO:
- 1, wherein the variant amino acid sequence comprises one or more amino acid substitutions at positions selected from F6, N7, G9, R13, H14, R16, I18, R20, R21, A26, L28, F29, and R38 of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.