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US 12,168,700 B2Granted
Therapeutic use of mitochondria and combined mitochondrial agents
AssigneesChildren's Medical Center Corporation, Beth Israel Deaconess Medical Center, Inc.
InventorsJames D. McCully, Sidney Levitsky, Douglas B. Cowan, Pedro J. del Nido, Sitaram M. Emani
Life of this patent
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Abstract
The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.
Claims24
A method of transplanting an organ into a human subject, the method comprising:
- contacting the organ with an effective amount of a composition comprising exogenous mitochondria such that the mitochondria are incorporated within the organ to generate a modified organ comprising the exogenous mitochondria;
- and transplanting the organ to the human subject.
A method of transplanting a heart into a human subject, the method comprising:
- contacting the heart with an effective amount of a composition comprising exogenous mitochondria such that the mitochondria are incorporated within the heart to generate a modified heart comprising the exogenous mitochondria;
- and transplanting the heart to the human subject.
A method of transplanting a kidney into a human subject, the method comprising:
- contacting the kidney with an effective amount of a composition comprising exogenous mitochondria such that the mitochondria are incorporated within the kidney to generate a modified kidney comprising the exogenous mitochondria;
- and transplanting the kidney to the human subject.
A method of transplanting a liver into a human subject, the method comprising:
- contacting the liver with an effective amount of a composition comprising exogenous mitochondria such that the mitochondria are incorporated within the liver to generate a modified liver comprising the exogenous mitochondria;
- and transplanting the liver to the human subject.
Dependencies are inferred from the claim text.