Heme sequesting peptides and uses therefor
AssigneeBoard of Regents, The University of Texas System
InventorLi Zhang
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Abstract
The disclosure relates to engineered heme sequestering peptides and their use in treating cancer and inhibiting microbial infections and colonization.
Claims27
A method of treating small cell carcinoma comprising administering to said subject a recombinant heme sequestering peptide (HeSP) comprising an amino acid substitution of Q32H in the Q32 loop of Yersinia pestis HasA.
A method of treating cancer comprising administering to said subject (i) radiation, chemotherapy and/or immunotherapy and (ii) a recombinant heme sequestering peptide (HeSP) comprising an amino acid substitution of Q32H in the Q32 loop of Yersinia pestis HasA.
Dependencies are inferred from the claim text.