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US 12,168,671 B2Granted
Phosphohistidine mimetics and antibodies to same
AssigneeThe Trustees of Princeton University
InventorsTom W. Muir, Rob C. Oslund, Jung-Min Kee
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Abstract
Provided are phosphonopyrazole-based phosphohistidine analogs that are useful as haptens for the preparation of immunogens, immunogens that include these haptens linked to carrier molecules, antibodies thereto and uses of these antibodies, haptens, immunogens and phosphohistidine analogs.
Claims1
A phosphonopyrazole of formula I:
- wherein:
- R is
- R2, and R3, are each, independently, H or alkyl;
- X is —CH2—CH2—;
- Y is NHBoc, where Boc is tert-butoxycarbonyl protecting group.
2 more elements
Dependencies are inferred from the claim text.