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AssigneeCureVac AG
InventorsSusanne Rauch, Kim Ellen Schwendt, Benjamin Petsch
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The present invention is directed to an artificial nucleic acid and to polypeptides suitable for use in treatment or prophylaxis of an infection with Norovirus or a disorder related to such an infection. In particular, the present invention concerns a Norovirus vaccine. The present invention is directed to an artificial nucleic acid, polypeptides, compositions and vaccines comprising the artificial nucleic acid or the polypeptides. The invention further concerns a method of treating or preventing a disorder or a disease, first and second medical uses of the artificial nucleic acid, polypeptides, compositions and vaccines. Further, the invention is directed to a kit, particularly to a kit of parts, comprising the artificial nucleic acid, polypeptides, compositions and vaccines.
A pharmaceutical composition comprising at least one artificial RNA molecule and at least three different RNA coding regions encoding three different Norovirus VP1 polypeptides, said coding regions each encoding a different GII.4 VP1 polypeptide and having at least 90% identity to the polypeptide coding sequence of SEQ ID NOs:
Dependencies are inferred from the claim text.