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US 12,168,046 B2Granted
Mycobacterial antigen compositions and methods of use
AssigneeChildren's National Medical Center
InventorsMichael Keller, Catherine Bollard, Patrick Hanley, Conrad Russell Cruz, Haili Lang, Shabnum Patel
Life of this patent
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Abstract
The present disclosure relates, at least in part, to mycobacterial polynucleotides and polypeptides, to fragments or variants thereof, to cells comprising the mycobacterial polynucleotides and polypeptides, to cells comprising the mycobacterial polynucleotides and polypeptides, that are engineered to expand T-cells ex vivo, and to methods of use thereof.
Claims3
A method of expanding T cells ex vivo, the method comprising:
- culturing one or a plurality of T-cells;
- contacting the one or plurality of T-cells with:
- a polypeptide comprising an amino acid sequence coding for an Ag85B antigen at least 70% identical to SEQ ID NO:
- 6 from a Mycobacterium species,
- a polypeptide comprising an amino acid sequence coding for a PPE68 antigen at least 70% identical to SEQ ID NO:
- 7 from a Mycobacterium species,
- a polypeptide comprising an amino acid sequence coding for an ESXA antigen at least 70% identical to SEQ ID NO:
- 8 from a Mycobacterium species,
- a polypeptide comprising an amino acid sequence coding for an ESXB antigen at least 70% identical to SEQ ID NO:
- 9 from a Mycobacterium species, and
- a polypeptide comprising an amino acid sequence coding for an ADK antigen at least 70% identical to SEQ ID NO:
- 10 from a Mycobacterium species.
9 more elements
Dependencies are inferred from the claim text.