Methods and compositions for wound healing

A method of treating a wound comprising applying a device to the surface of wound, the device comprising:

• a first polymer layer comprising a first bioactive agent, wherein the first polymer layer is a nanoscale polymer multilayer comprising alternating layers of at least one positively charged polyelectrolyte and at least one negatively charged polyelectrolyte;
• a second polymer layer comprising a second bioactive agent, wherein the second polymer layer is a water soluble microscale polymer layer;
• and
• a third polymer layer positioned in between the first and second polymer layers so that the three polymer layers are stacked in a sandwich-type structure, wherein the third polymer layer is a water soluble microscale polymer layer formed from a different polymer than the second polymer layer.