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US 12,163,960 B2Granted
Compositions and methods for predicting therapeutic outcome
AssigneeWashington University
InventorsJieya Shao, Marc Diamond
Life of this patent
Estimating the term…
Abstract
The present disclosure provides methods to quantify VCP phosphorylation at specific amino acid residue to predict responsiveness of a subject having a cancer or tumor to a genotoxic treatment, guide treatment decisions, select subjects for clinical trials, and evaluate the clinical efficacy of certain therapeutic interventions.
Claims6
An isolated antibody that specifically binds to the pSer784 phosphorylation site of valosin-containing protein (pSer784-VCP) wherein the antibody comprises:
- (a) a light chain variable region comprising a complementarity determining region 1 (CDR1) comprising the amino acid sequence set forth in SEQ ID NO:13;
- a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:
- 14, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:
- 15;
- and (b) a heavy chain variable region comprising a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:
- 10, CDR2 comprising the amino acid sequence set forth in SEQ ID NO:
- 11, a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:
- 12.
5 more elements
Dependencies are inferred from the claim text.