Non-invasive method and kit for capturing and isolating fetal cells from mother
OwnerJing Zhanginventor
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Abstract
Provided are a promoter of a gene specifically expressed in fetal trophoblast cells and a gene specifically expressed in fetal nucleated red blood cell-specific expression gene, as well as a recombinant herpes simplex virus type I obtained by replacing the wild type promoter of the genomic ICP of the recombinant herpes simplex virus type I with the aforesaid promoter and preparation and use thereof. Also provided are a diagnostic kit for prenatal screening and use thereof, as well as a method for isolating fetal cells from a maternal blood sample in pregnancy.
Claims4
A recombinant herpes simplex virus type I, wherein the virus has a pathogenicity-related ICP34.5 gene fragment removed, has the ICP wild type promoter of the viral genome replaced with a promoter of a gene specifically expressed in fetal trophoblast cells or a gene specifically expressed in fetal nucleated red blood cells, and has a marker for tracing the recombinant herpes simplex virus type I inserted into the virus.
Dependencies are inferred from the claim text.