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US 12,162,997 B2Granted
Facile assembly of soft nanoarchitectures and co-loading of hydrophilic and hydrophobic molecules via flash nanoprecipitation
AssigneeNorthwestern University
InventorsEvan A. Scott, Sean D. Allen
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Abstract
Described herein are flash nanoprecipitation methods capable of encapsulating hydrophobic molecules, hydrophilic molecules, bioactive protein therapeutics, or other target molecules in amphiphilic copolymer nanocarriers.
Claims14
A polymersome comprising:
- poly(ethylene glycol)-bl-poly(propylene sulfide) (PEG-bl-PPS);
- and
- rapamycin;
- wherein the polymersome comprises both an aqueous core and a lipophilic bilayer membrane.
1 more element
A polymersome loaded with rapamycin produced by a flash precipitation method comprising the steps of:
- (i) providing an organic phase solution comprising poly(ethylene glycol)-bl-poly(propylene sulfide) (PEG-bl-PPS) and a process solvent, wherein the PEG-bl-PPS has a glass transition temperature below 0° C.,
- (ii) providing an aqueous phase solution comprising an aqueous solvent and the rapamycin,
- (iii) mixing the organic phase solution and the aqueous phase solution by impingement to form a mixture, and
- (iv) introducing the mixture into a reservoir to cause precipitation of the PEG-bl-PPS as the polymersome loaded with rapamycin,
- wherein the rapamycin is provided in at least one of the process solvent and the aqueous solvent, and
- wherein the polymersome comprises both an aqueous core and a lipophilic bilayer membrane.
3 more elements
Dependencies are inferred from the claim text.