Compositions targeting apoptosis-associated speck-like protein with caspase activation and recruitment domain (ASC) and methods of use
AssigneesUNM Rainforest Innovations, Bryce Chackerian, Kiran Bhaskar, Jonathan Hulse
InventorsBryce Chackerian, Kiran Bhaskar, Jonathan P. Hulse
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Abstract
An immunogen includes an immunogenic carrier and an antigenic apoptosis-associated speck-like protein containing a caspase activation and recruitment domain (ASC) peptide linked to the immunogenic carrier. In one or more embodiments, the immunogenic carrier is a Qβ virus-like particle (VLP). The immunogen may be formulated into a composition useful for treating inflammatory medical conditions.
Claims22
An immunogen comprising:
- an immunogenic carrier comprising a Qβ bacteriophage virus-like particle (VLP);
- and
- a first antigenic apoptosis-associated speck-like protein containing a caspase activation and recruitment domain (ASC) peptide linked to the immunogenic carrier.
A method for treating an inflammatory condition in a subject, the method comprising administering to the subject a therapeutically effective amount of a composition comprising an immunogen, the immunogen comprising:
- a first immunogenic carrier comprising a Qβ bacteriophage virus-like particle (VLP);
- and
- a first antigenic apoptosis-associated speck-like protein containing a caspase activation and recruitment domain (ASC) peptide linked to the first immunogenic carrier.
Dependencies are inferred from the claim text.