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US 12,162,902 B2Granted
Decarboxylase inhibitors for treating Parkinson's disease
AssigneeSail Biomedicines
InventorsDevin Forest Reed Doud, Timothy Briggs, Steven Taylor, Elijah Bogart, John Proudfoot, Dinara Shashanka Gunasekera, Spencer Cory Peck, Angela She, William McElroy, Bernard Lanter, Michael Rutlin
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Abstract
Provided are inhibitors of pathogenic, bacterial metabolite production and conjugates of the inhibitors. Also provided are pharmaceutical compositions containing the inhibitors or conjugates and methods of using the same.
Claims19
A compound chosen from the following compounds
- and pharmaceutically acceptable salts thereof.
A compound chosen from the following compounds
- and pharmaceutically acceptable salts thereof.
A compound of formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein
- n is 0 or 1;
- R1 is H or —ORA, wherein RA is H, —C(O) C1-6 alkyl, or an acylated sugar;
- R2 is H, halogen, amino, C1-6 alkyl, or —ORA, wherein RA is H or an acylated sugar;
- R3 is H, a halogen, or C1-6 alkyl optionally substituted with one or more halogens;
- R4 is H, —NH2, —C(O)OCH3, or an acylated sugar;
- R5 is —C(O)OH, —C(O)OC1-6 alkyl, —C(O)Oglycoside, —C(O)NHOH, or —C(O)O(acylated sugar);
- and
- R6 is H, halogen, or optionally substituted C1-6 alkyl;
- provided that at least one RA is present or that R3 and/or R6 comprise a halogen;
- provided that at least one of R1 and R2 is —ORA;
- provided that, when both R1 and R2 are —ORA wherein RA is H, then R3 is not H;
- and
- provided that, when n is 0, R1 is —ORA wherein RA is H, R2 is H or halogen, R4 is H or NH2, R5 is —C(O)OH, and R6 is H or optionally substituted C1 alkyl, then R3 is not H.
12 more elements
Dependencies are inferred from the claim text.