Peptidomimetic-based antibody surrogate for HER2
AssigneeUniversity of South Florida
InventorsJianfeng Cai, Mengmeng Zheng
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Abstract
Disclosed are cyclic γ-amino acid peptide compounds, methods of using said compounds, and kits comprising said compounds. More specifically, disclosed are human epidermal growth factor receptor 2 (HER2) specific cyclic γ-amino acid peptide compounds, methods of using said compounds in the treatment of cell proliferative diseases or disorders, methods of detecting HER2 using the compounds, and kits comprising the compounds.
Claims29
A cyclic y-amino acid peptide compound (cyclic γ-AA) comprising:
- formula (i)
- wherein R1 comprises H, a tag, a linker or a linker-tag complex.
A pharmaceutical composition comprising a cyclic γ-amino acid peptide (cyclic γ-AA) selected from the compounds having the formula:
- formula (i)
- wherein R1
- comprises H, a tag, a linker or a linker-tag complex,
- formula (iii)
- or formula (iv)
- , and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.