MCL-1 inhibitors

A compound, according to Formula (III):

• or a pharmaceutically acceptable salt thereof, wherein:
• is a single or double bond;
• R1 is C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C3-10cycloalkyl, C6-10aryl, 3-12 membered heterocyclyl, 5-10 membered heteroaryl, —OR7, or —NR8R9, wherein
• said C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C3-10cycloalkyl, C6-10aryl, 3-12 membered heterocyclyl, and 5-10 membered heteroaryl of R1 are independently optionally substituted with 1-5 R10 groups;
• each R2, R3, R4, and R5 is independently hydrogen or C1-6alkyl;
• R6 is hydrogen or halo;
• each R7 is independently hydrogen, or C1-6alkyl, wherein
• said C1-6alkyl is optionally substituted with from 1-5 R10;
• each R8 and R9 is independently hydrogen, C1-6alkyl, C3-10cycloalkyl, C1-6heteroalkyl, 3-12 membered heterocyclyl, C6-10aryl, or 5-10 membered heteroaryl, or R8 and R9 together with the atoms to which they are attached form a 3-12 membered heterocycle, wherein
• said C1-6alkyl, C3-10cycloalkyl, C1-6heteroalkyl, 3-12 membered heterocyclyl, C6-10aryl, and 5-10 membered heteroaryl of R8 and R9 are independently optionally substituted with 1-5 R10;
• each R10 is independently C1-6alkyl, C3-10cycloalkyl, C1-6heteroalkyl, 3-12 membered heterocyclyl, C6-10aryl, 5-10 membered heteroaryl, halo, oxo, —ORa, —C(O)Ra, —C(O)ORa, —C(O)NRaRb, —OC(O)NRaRb, —NRaRb, —NRaC(O)Rb, —NRaC(O)ORb, —S(O)qRa, —S(O)2NRaRb, —NRaS(O)2Rb, —N3, —CN, or —NO2, or two R10 groups form a fused, spiro, or bridged C3-10 cycloalkyl or 3-12 membered heterocyclyl, wherein
• each C1-6alkyl, C1-6 heteroalkyl, C3-10cycloalkyl, C6-10aryl, 3-12 membered heterocycle, and 5-10 membered heteroaryl of R10 is independently optionally substituted with 1-5 R20 groups;
• each Ra and Rb is independently hydrogen, C1-6alkyl, C2-6 alkenyl, C3-10cycloalkyl, C1-6heteroalkyl, 3-12 membered heterocyclyl, C6-10aryl, or 5-10 membered heteroaryl, or Ra and Rb together with the atoms to which they are attached form a 3-12 membered heterocyclyl wherein
• said each C1-6alkyl, C2-6 alkenyl, C3-10cycloalkyl, C1-6heteroalkyl, 3-12 membered heterocyclyl, C6-10aryl, 5-10 membered heteroaryl of Ra and Rb is independently optionally substituted with 1-5 R20 groups;
• each R20 is independently C1-6 alkyl, C3-10cycloalkyl, C1-6heteroalkyl, 3-12 membered heterocyclyl, C6-10aryl, 5-10 membered heteroaryl, hydroxyl, C1-6 alkoxy, amino, —CN, —C(O)H, —C(O)NH2, —C(O)NH(C1-6 alkyl), —C(O)N(C1-6 alkyl)2, —COOH, —C(O)C1-6alkyl, —C(O)OC1-6alkyl, or halogen;
• n is 0, 1, or 2;
• and
• q is 0, 1, or 2.