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US 12,161,777 B2Granted
Flowable hemostatic suspension
AssigneeDavol Inc.
InventorsKeith Greenawalt, Christopher Bowley, Frederick H. Strickler, Jr., Andrew C. Yang, Rajendra R. Bhat, Jessica Powell, Michael T. Cash, Aaron D. Strickland, Esther M. Valliant
Life of this patent
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Abstract
Compositions and methods related to flowable hemostats that crosslink during and/or after application to a bleeding site are generally described.
Claims18
A method for controlling bleeding, comprising:
- applying a precursor composition dissolved or suspended in a non-aqueous solvent to a bleeding/wound site, wherein the precursor composition is non-reactive in the non-aqueous solvent but capable of crosslinking in an aqueous solvent;
- so that crosslinking of the precursor composition to form a hemostatic hydrogel able to stop or reduce bleeding is initiated upon application to the bleeding/wound site.
A method for controlling bleeding, comprising:
- applying a precursor composition dissolved or suspended in an aqueous solvent at a first pH to a bleeding/wound site, wherein the first pH is less than 7, and wherein the precursor composition is non-reactive at the first pH of the aqueous solvent but capable of crosslinking in an aqueous solvent at a second, physiological pH;
- so that crosslinking of the precursor composition to form a hemostatic hydrogel able to stop or reduce bleeding is initiated upon application to the bleeding/wound site.
A method for controlling bleeding, comprising:
- applying a first flowable precursor component and a second flowable precursor component to a bleeding/wound site, wherein the first flowable precursor component crosslinks with the second flowable precursor component to form a hemostatic hydrogel able to stop or reduce bleeding at the bleeding/wound site,
- wherein:
- the first flowable precursor component comprises albumin and an acid and/or acidic buffer, and
- the second flowable precursor component comprises a crosslinking initiator, a component that is able to crosslink with the first flowable precursor component, a base, and/or a basic buffer.
1 more element
A method for controlling bleeding, comprising:
- applying a first flowable precursor component and a second flowable precursor component to a bleeding wound site, wherein the first flowable precursor component crosslinks with the second flowable precursor component to form a hemostatic hydrogel able to stop or reduce bleeding at the bleeding wound site, and wherein at least one of the first flowable precursor component and/or the second flowable precursor component comprises porous microspheres comprising crosslinked hydrolyzed starch.
Dependencies are inferred from the claim text.