Sustained release biodegradable intracanalicular inserts comprising a hydrogel and an active agent
AssigneeOcular Therapeutix, Inc.
InventorsCharles D. Blizzard, Rami El-Hayek, Michael Goldstein, Peter Jarrett, Andrew Vanslette
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Abstract
Provided herein are sustained release biodegradable intracanalicular inserts comprising a hydrogel and an active agent, methods of treating or preventing an ocular disease in a subject in need thereof by administering such inserts as well as methods of manufacturing such inserts.
Claims26
A method of treating or preventing an ocular disease in a human subject in need thereof, the method comprising inserting into the canaliculus of the human subject a sustained release biodegradable intracanalicular insert comprising a hydrogel and an active agent, wherein the hydrogel comprises a polymer network comprising polyethylene glycol units having an average molecular weight in the range of from about 2,000 to about 100,000 Daltons, wherein the polymer network comprises multi-arm polymer units comprising 4-8 polyethylene glycol units and cross-linking units comprising fluorescein-conjugated trilysine amide units, wherein the active agent is in the form of particles and wherein the active agent particles are dispersed within the hydrogel.
Dependencies are inferred from the claim text.