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US 12,161,730 B2Granted
Methods for making ultrasound contrast agents
AssigneeLantheus Medical Imaging, Inc.
InventorsSimon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
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Abstract
Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
Claims27
A method of ultrasound contrast imaging a subject comprising
- (a) forming a phospholipid solution that comprises
- (i) a phospholipid blend comprising one or more phospholipids and a non-aqueous solvent, wherein the phospholipid blend is formed in the presence of one or two but not all three of methanol, toluene and methyl t-butyl ether (MTBE), and
- (ii) calcium and/or magnesium divalent metal cation present at a total divalent metal cation concentration of less than 0.7 parts per million (ppm),
- (b) combining the phospholipid solution with an aqueous solution to form a phospholipid suspension,
- (c) activating the phospholipid suspension with a perfluorocarbon gas to form lipid-encapsulated gas microspheres,
- (d) administering the lipid-encapsulated gas microspheres to a subject, and
- (e) obtaining an ultrasound image of the subject.
4 more elements
A method of ultrasound contrast imaging a subject comprising
- (a) forming a phospholipid blend comprising one or more phospholipids, in the presence of one or two but not all three of methanol, toluene and methyl t-butyl ether (MTBE),
- (b) combining the phospholipid blend with a non-aqueous solvent to form a phospholipid solution having calcium and/or magnesium divalent metal cation present at a total divalent metal cation concentration of less than 0.7 parts per million (ppm),
- (c) combining the phospholipid solution with an aqueous solution to form a phospholipid suspension,
- (d) activating the phospholipid suspension with a perfluorocarbon gas to form lipid-encapsulated gas microspheres,
- administering the lipid-encapsulated gas microspheres to a subject, and obtaining an ultrasound image of the subject.
2 more elements
Dependencies are inferred from the claim text.