Malaria immunogen and methods for using same
AssigneesUNM Rainforest Innovations, The Johns Hopkins University, Vaxine Pty Ltd
InventorsBryce Chackerian, David S. Peabody, Nikolai Petrovsky, Lucia Jelinkova, Fidel Zavala
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Abstract
An immunogen useful for treating malaria generally includes an immunogenic carrier and an antigenic malaria circumsporozoite protein (CSP) peptide that includes the peptide NPDPNANPNVDPNAN (amino acids 5-19 of SEQ ID NO:1) linked to the immunogenic carrier. The immunogen may be administered to a subject having or at risk of having malaria.
Claims12
An immunogen comprising:
- an immunogenic carrier comprising a Qβ bacteriophage virus-like particle (VLP);
- and
- an antigenic malaria circumsporozoite protein (CSP) junction region peptide comprising NPDPNANPNVDPNAN (amino acids 5-19 of SEQ ID NO:1) linked to the immunogenic carrier.
A method of treating malaria in an individual, the method comprising administering a therapeutically effective amount of an immunogen to the individual, the immunogen comprising:
- an immunogenic carrier comprising a Qβ bacteriophage virus-like particle (VLP);
- and
- an antigenic malaria circumsporozoite protein (CSP) junction region peptide comprising NPDPNANPNVDPNAN (amino acids 5-19 of SEQ ID NO:1) linked to the immunogenic carrier.
Dependencies are inferred from the claim text.