Compositions and methods for enzymatic disruption of bacterial biofilms
AssigneeResearch Institute At Nationwide Children's Hospital
InventorsSteven David Goodman, Lauren Opremcak Bakaletz
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Abstract
Provided herein are methods to inhibit or disrupt a bio film comprising contacting the bio film with an agent that cleaves the Holliday junction (HJ) structure in the bio film.
Claims17
A method to inhibit or disrupt a biofilm comprising contacting the biofilm with an agent that cleaves the Holliday junction (HJ) structure in the biofilm, wherein the agent is an HJ-specific endonuclease, thereby inhibiting or disrupting said biofilm.
A method to inhibit or disrupt a biofilm or treat a disease or condition incident to a biofilm infection in a subject in need thereof, comprising administering to the subject an effective amount of an agent that cleaves the Holliday junction (HJ) structure in the biofilm, wherein the agent is an HJ-specific endonuclease, thereby inhibiting or disrupting said biofilm.
Dependencies are inferred from the claim text.