SAP FC fusion proteins and methods of use
AssigneesAttralus, Inc., University of Tennessee Ressearch Foundation
InventorsJaume Pons, Jonathan S. Wall
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Abstract
The present invention relates to SAP-Fc fusion proteins comprising one or more amino acid substitution, for example, C226S and/or C229S. In some aspects, the fusion protein comprises a structure represented by the following formula, from N-terminus to C-terminus, SAP-Fc1-L1-Fc2, wherein Fc1 is a first Fc domain sequence comprising hinge-CH2-CH3, L1 is a linker, and Fc2 is a second Fc domain sequence comprising hinge-CH2-CH3. The present invention also relates to methods of treating amyloid related diseases by administering said SAP-Fc fusion proteins to a subject in need thereof.
Claims19
A fusion protein comprising a structure represented by the following formula, from N-terminus to C-terminus, SAP-Fc1-L1-Fc2, wherein Fc1 is a first Fc domain sequence comprising hinge-CH2-CH3, L1 is a linker, and Fc2 is a second Fc domain sequence comprising hinge-CH2-CH3, wherein SAP is a human serum amyloid P (SAP) component protein, wherein Fc1 and Fc2 each comprise amino acid substitutions C226S and C229S, according to EU numbering, wherein the fusion protein comprises the amino acid sequence set forth in SEQ ID NO:
- 1 with or without the C-terminal lysine, or SEQ ID NO:
- 23 with or without the C-terminal lysine.
A fusion protein comprising a structure represented by the following formula, from N-terminus to C-terminus, SAP-Fc1-L1-Fc2, wherein Fc1 is a first Fc domain sequence comprising hinge-CH2-CH3, L1 is a linker, and Fc2 is a second Fc domain sequence comprising hinge-CH2-CH3, wherein SAP is a human serum amyloid P (SAP) component protein, wherein Fc1 and Fc2 each comprise amino acid substitutions C226S and C229S, according to EU numbering, wherein the human SAP comprises the amino acid sequence set forth in SEQ ID NO:
- 20.
Dependencies are inferred from the claim text.