Compositions and methods for targeting cells
AssigneesChildren's Medical Center Corporation, Politecnico Di Milano, Dana-Farber Cancer Institute, Inc.
InventorsMarco Peviani, Alessandra Biffi, Davide Moscatelli, Umberto Capasso Palmiero, Renato Auriemma, Mattia Sponchioni, Letterio Salvatore Politi
Life of this patent
Estimating the term…
Abstract
The present invention provides compositions and methods for targeting cells for therapeutic and/or diagnostic purposes, e.g., delivery of therapeutic and/or diagnostic agents to a cell. Nanoparticles and polymers functionalized with capture molecules, reporter molecules, and/or therapeutic agents are provided for the treatment or prevention of disease, including neurological diseases associated with neuroinflammation, and cancer.
Claims18
A functionalized polymer comprising a first monomer:
- 2-Methacryloyloxyethyl phosphorylcholine (MPC), and a second monomer:
- methacrylate/amide polyethylene glycol (PEG) comprising an amine or azide covalently linked with
- a translocator protein (TSPO) ligand precursor having the structure:
Dependencies are inferred from the claim text.