Back to results
US 12,161,631 B2Granted
Liquid pharmaceutical formulation
AssigneeProject Pharmaceutics GmbH
InventorsAndreas Schuetz, Klaus Hellerbrand
Life of this patent
Estimating the term…
Abstract
The present invention relates to a liquid pharmaceutical formulation, which is stable at room temperature, being essentially free of water, comprising a) at least one easily degradable active pharmaceutical ingredient, b) at least one pharmaceutically acceptable organic solvent and c) at least one pharmaceutically acceptable alkaline earth metal salt and its use in medicine.
Claims22
A method of treating a subject having cancer, the method comprising:
- providing a liquid pharmaceutical formulation having a water content of below 1.0% (w/w) water, the liquid pharmaceutical formulation comprising
- a) Bendamustine as an active pharmaceutical ingredient;
- b) at least one pharmaceutically acceptable organic solvent comprising propylene glycol, polyethylene glycol 400 (PEG 400) or a mixture of propylene glycol and PEG 400;
- and
- c) a calcium salt;
- optionally diluting the liquid pharmaceutical formulation with water for injection, saline or a buffer prior to administration;
- and
- administering the liquid pharmaceutical formulation to the subject.
5 more elements
Dependencies are inferred from the claim text.