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US 12,158,471 B2Granted
Recombinant amebocyte lysate and uses thereof
AssigneeCharles River Laboratories, Inc.
InventorsNorman R. Wainwright, Masakazu Tsuchiya, John Dubczak, Foster T. Jordan
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Abstract
The invention relates generally to hybrid amebocyte lysate compositions (including both native and recombinant components) and their use in detecting and/or quantifying endotoxin in a sample.
Claims11
A composition comprising a recombinant factor C, a recombinant factor B, and a recombinant pro-clotting enzyme,
- wherein the recombinant factor C lacks (α-2,3)-linked terminal sialic acid;
- and
- wherein the recombinant Factor C comprises the amino acid sequence of SEQ ID NO:
- 2, the recombinant Factor B comprises the amino acid sequence of SEQ ID NO:
- 5, and the recombinant pro-clotting enzyme comprises the amino acid sequence of SEQ ID NO:
- 8.
3 more elements
Dependencies are inferred from the claim text.