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US 12,158,402 B2Granted
Manipulating and detecting biological samples
AssigneeSingular Genomics Systems, Inc.
InventorsYuji Ishitsuka, Zhenmin Hong, Eli N. Glezer, Hu Cang, William Dempsey, Weiqiao Ding, Jaekyung Koh, Mohammad Vatankhah Varnosfaderani
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Abstract
Disclosed herein, inter alia, are compositions and methods for efficient transfer and analyses of cellular material, tissue samples, such as tissue sections, using carrier substrates.
Claims28
A system configured to form a section of biological tissue, comprising:
- a cutting device forming a sharp edge;
- a sample construct formed of a tissue section bonded to a carrier substrate, wherein the tissue section bonds to the carrier substrate via a first bond having a first adhesion strength;
- and
- a receiving substrate;
- wherein the sharp edge of the cutting device is configured to cut through both the tissue section and the carrier substrate of the sample construct to form a construct portion,
- wherein the construct portion includes a portion of the tissue section and a portion of the carrier substrate, and
- wherein the portion of the tissue section bonds to the receiving substrate via a second bond having a second adhesion strength, wherein the second adhesion strength is greater than the first adhesion strength.
4 more elements
Dependencies are inferred from the claim text.