Melt processed viral nanoparticle constructs
AssigneeCase Western Reserve University
InventorsNicole F. Steinmetz, Jonathan Pokorski
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Abstract
A melt processed viral nanoparticle construct for delivery of virus or virus-like particles to a site of interest includes a degradable polymer matrix and a plurality of virus or virus-like particles encapsulated within the degradable polymer matrix. The nanoparticle construct upon administration to the site of interest providing a sustained release of the virus or virus-like particles and/or nanoparticles upon degradation of the polymer matrix.
Claims20
A melt processed degradable viral nanoparticle construct for delivery of virus or virus-like particles to a site of interest, the nanoparticle construct comprising:
- a degradable polymer matrix, and
- a plurality of virus or virus-like particles encapsulated within the degradable polymer matrix, the nanoparticle construct upon administration to the site of interest providing a sustained release of the virus or virus-like particles upon degradation of the polymer matrix, the virus or virus-like particles upon release from the degradable polymer matrix having the same or substantially similar structural and/or biochemical characteristics as the virus or virus-like particles prior to melt processing.
The nanoparticle construct 2, wherein the degradable polymer material has melt temperature below the degradation temperature of the virus or virus-like particles.
Dependencies are inferred from the claim text.