Method for delivering RNA to neurons to treat herpes infections
AssigneesUniversity of Florida Research Foundation, Inc., Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
InventorsDavid C. Bloom, Alfred S. Lewin, Donna M. Neumann, Zachary L. Watson, Sonal Sanjeev Tuli, Gregory Scott Schultz
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Abstract
Aspects of the application relate to methods and compositions for delivering therapeutic nucleic acids to neural cells or tissue in a subject. Additional aspects of the application relate to therapeutic nucleic acids, for example therapeutic ribozymes, that are useful for inhibiting viral reactivation in a subject.
Claims14
A method comprising administering a recombinant viral vector to a subject having a neurotropic virus infection, wherein the vector comprises a nucleic acid encoding a ribozyme that specifically binds and/or cleaves a latency-associated region transcript of a neurotropic virus, wherein the latency-associated region transcript comprises a TAL transcript, and wherein the ribozyme comprises any one of the nucleic acid sequences of SEQ ID NOs:
- 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, and 29.
A method comprising administering a recombinant viral vector to a subject having a neurotropic virus infection, wherein the vector comprises a nucleic acid encoding a ribozyme that specifically binds and/or cleaves a latency-associated region transcript of a neurotropic virus, wherein the latency-associated region transcript comprises an ATAL transcript, and wherein the ribozyme comprises any one of the nucleic acid sequences of SEQ ID NOs:
- 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, and 54.
Dependencies are inferred from the claim text.