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US 12,156,908 B2Granted
Virus like nanoparticle compositions and methods thereof
AssigneesRegents of the University of Minnesota, New York Blood Center, Inc.
InventorsFrank Jonathan Lee, Qibin Geng, Jian Shang, Marc Jenkins, Sung-Wook Hong, Lanying Du, Wanbo Tai, Yushun Wan
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Abstract
The present disclosure provides virus like nanoparticles (VLPs), which are capable of displaying multiple copies of a SARS-CoV-2 antigen, for eliciting protective immunity against a SARS-CoV-2 infection, as well as polypeptides, compositions and methods thereof.
Claims28
A virus-like nanoparticle (VLP) comprising:
- 1) a plurality of oligomerized VLP monomer polypeptides, wherein each VLP monomer polypeptide comprises an Fc binding domain amino acid sequence operably linked to a lumazine synthase (LS) amino acid sequence;
- and
- 2) a plurality of S-antigen-Fc polypeptides, wherein each S-antigen-Fc polypeptide comprises a SARS-CoV-2 Spike protein domain amino acid sequence operably linked to a Fc domain amino acid sequence.
The composition of 17, which is a vaccine composition comprising one or more adjuvant(s).
Dependencies are inferred from the claim text.