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US 12,156,906 B2Granted
Immunologically active fragments of toxoplasma gondii
AssigneeWashington University
InventorsLaurence David Sibley, Iti Saraav, Qiuling Wang, Mary Savari Dhason
Life of this patent
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Abstract
T. gondii proteins MIC1 and MIC4 are components of excretory/secretory antigens (ESA) that elicit delayed type hypersensitivity (DTH) responses in infected animals. These antigens are capable of inducing IFN-g secretion by splenic T cells (ELISPOT assay), stimulating T cells to produce cytokines that recruit inflammatory monocytes and neutrophils resulting in a positive luminol test (luminol ear assay), and eliciting a positive skin test in the guinea pig.
Claims15
A composition comprising an antigen consisting of the amino acid sequence set forth in SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.