Magnesium-containing oxytocin formulations and methods of use
AssigneeTonix Pharma Limited
InventorsDean Carson, David C. Yeomans
Life of this patent
Estimating the term…
Abstract
Disclosed are methods and compositions for the treatment of autism spectrum disorder, related disorders and symptoms of such disorders, comprising co-administration of an oxytocin peptide and magnesium ions. Co-administration of an oxytocin peptide and magnesium ions results in a synergistic or enhanced effect on reducing social and communication deficits in a patient suffering from an autism spectrum disorder.
Claims29
A method for treating a disorder selected from an autism spectrum disorder, a social anxiety disorder, or a social communication disorder, comprising administering to a subject in need thereof an oxytocin peptide and a magnesium salt formulated in an aqueous solution for intranasal administration, wherein the aqueous solution comprises about 8 μg to about 1000 μg of the oxytocin peptide, wherein the magnesium salt is capable of providing between 0.11% to 1.65% (w/v) of magnesium ions, and wherein the aqueous solution has an oxytocin peptide to magnesium ions molar ratio selected from the group consisting of:
- about 1:1000, about 1:1100, about 1:1200, about 1:1400, and about 1:1600.
A method for treating a disorder selected from an autism spectrum disorder, a social anxiety disorder, or a social communication disorder, comprising administering to a subject in need thereof an oxytocin peptide and a magnesium salt formulated in an aqueous solution for intranasal administration, wherein the aqueous solution comprises about 8 μg to about 1000 μg of the oxytocin peptide, wherein the magnesium salt is capable of providing 0.11% to 1.65% (w/v) of magnesium ions, wherein the aqueous solution has an oxytocin peptide to magnesium ions molar ratio selected from the group consisting of the ratios:
- about 1:1000, about 1:1100, about 1:1200, about 1:1400, and about 1:1600, and wherein the volume of the aqueous solution administered is between about 5 μL and about 1000 μL.
Dependencies are inferred from the claim text.