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US 12,156,891 B2Granted
Cardiac stem cells for cardiac repair
AssigneeUniversity of Maryland, Baltimore
InventorSunjay Kaushal
Life of this patent
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Abstract
Embodiments of the disclosure concern compositions and methods of use related to particular c-kit+ mesenchymal cells, including cardiac stem cells, obtained from a pediatric or neonatal individual. In specific embodiments, the cells, or conditioned medium or partial or total secretomes thereof, are provided in an effective amount to an individual in need thereof.
Claims11
A pharmaceutical composition comprising genetically-engineered, human, neonatal cardiac stem cells and one or more pharmaceutically acceptable carriers, wherein the genetically-engineered, human, neonatal cardiac stem cells:
- (a) are positive for protein expression of c-kit and Nkx2.5,
- (b) are negative for protein expression of GATA4, CD31, and Isl1, and
- (c) comprise an exogenous nucleic acid construct that encodes SDF-1a, VEGF-A, PDGF-A, IL-6, or FGF-2.
Dependencies are inferred from the claim text.